LHPP

Across TCGA patient cohorts, LHPP protein abundance is significantly associated with the RNA expression of many other genes, with 15,972 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LHPP-associated genes across cancer lineages are LMOD1, ADH1B, and PTH1R. Each is linked with LHPP in more than 7 cancer types. Because this analysis shows association rather than direction, both LHPP-to-partner and partner-to-LHPP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHPP versus LMOD1 in UCEC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHPP→partner) and Y-score (partner→LHPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.458	+0.414	<.001	.001	3	8
BRCA	ADH1B →	+2.105	+0.313	<.001	.001	3	8
UCEC	PTH1R →	+1.030	+0.476	<.001	<.001	3	7
UCEC	ASPA →	+0.685	+0.337	.005	.005	3	7
UCEC	C7 →	+1.622	+0.338	.004	.008	3	7
UCEC	KIF20A →	-1.277	-0.415	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,972 associations by consensus.

LHPP vs LMOD1 — UCEC

Explore this scatter interactively →