LHPP

Across TCGA cell cohorts, LHPP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,094 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LHPP-associated GO terms across cancer lineages are Golgi vesicle budding, Regulation of protein localization to cell periphery, and Caveolin-mediated endocytosis. Each is linked with LHPP in more than 8 cancer types. Because this analysis shows association rather than direction, both LHPP-to-partner and partner-to-LHPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle budding grouped by LHPP-low versus LHPP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHPP→partner) and Y-score (partner→LHPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle budding →	+0.142	+0.772	<.001	.001	3	9
BONE	Regulation of protein localization to cell periphery →	+0.080	+0.758	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Caveolin-mediated endocytosis →	+0.135	+0.605	<.001	.001	3	9
STOMACH	Endosomal transport →	+0.086	+1.544	<.001	<.001	3	8
BONE	Flagellated sperm motility →	-0.077	-0.929	.003	<.001	2	9
LUNG_NSCLC_LUAD	Cilium movement involved in cell motility →	-0.052	-0.958	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,094 associations by consensus.

Golgi vesicle budding by LHPP expression — UPPER_AERODIGESTIVE_TRACT

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