Across TCGA patient cohorts, LHFPL5 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL5-associated genes across cancer lineages are ACC_pS79, ACC1, and JNK2. Each is linked with LHFPL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL5-to-partner and partner-to-LHFPL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL5→partner) and Y-score (partner→LHFPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.438	+3.331	.005	.005	3	2
UCEC	ACC1 →	+0.434	+2.700	.008	.006	3	1
UCEC	JNK2 →	+0.245	+3.026	.006	.018	3	1
UCEC	mTOR →	-0.152	-2.000	.037	.032	3	1
UCEC	Notch1 →	+0.142	+2.183	.025	.033	3	1
UCEC	p27_pT157 →	-0.064	-2.000	.014	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

LHFPL5 survival (RNA) · tumor vs normal (RNA) · all LHFPL5 data types