Across TCGA cell cohorts, LHFPL5 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LHFPL5-associated genes across cancer lineages are ZP2, NOBOX, and MAGEB4. Each is linked with LHFPL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL5-to-partner and partner-to-LHFPL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL5→partner) and Y-score (partner→LHFPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZP2 →	+0.182	+4.409	<.001	.005	3	1
BLOOD_Leukemia	NOBOX →	+0.054	+4.539	<.001	.007	3	1
BLOOD_Leukemia	MAGEB4 →	+0.046	+4.705	<.001	.003	3	1
BLOOD_Leukemia	KRTAP13-4 →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR5H6 →	+0.432	+4.705	<.001	.003	3	1
BLOOD_Leukemia	SLC5A8 →	+0.139	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LHFPL5 survival (RNA) · tumor vs normal (RNA) · all LHFPL5 data types