LHFPL4

Across TCGA patient cohorts, LHFPL4 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL4-associated genes across cancer lineages are NK cells, CD8+ naive T-cells, and Endothelial cells. Each is linked with LHFPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL4-to-partner and partner-to-LHFPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NK cells grouped by LHFPL4-low versus LHFPL4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL4→partner) and Y-score (partner→LHFPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NK cells →	+0.004	+5.597	.004	.040	3	1
UCEC	CD8+ naive T-cells →	+0.022	+2.475	.036	.011	3	1
UCEC	Endothelial cells →	-0.036	-1.957	.016	.010	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-3.116	.009	<.001	3	1
UCEC	Basophils →	+0.156	+2.321	.019	.034	3	1
UCEC	NKT →	-0.100	-2.560	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NK cells by LHFPL4 expression — STAD

Explore this box plot interactively →