LHFPL4

Across TCGA cell cohorts, LHFPL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,192 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LHFPL4-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair, and Positive regulation of DNA metabolic process. Each is linked with LHFPL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both LHFPL4-to-partner and partner-to-LHFPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by LHFPL4-low versus LHFPL4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL4→partner) and Y-score (partner→LHFPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of DNA repair →	+0.047	+1.364	<.001	.003	3	7
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.060	+1.508	<.001	.001	3	6
LUNG_SCLC	Positive regulation of DNA metabolic process →	+0.045	+1.659	<.001	<.001	3	5
LUNG_SCLC	Heterochromatin organization →	+0.060	+2.067	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Negative regulation of transcription by RNA polymerase III →	+0.107	+1.056	.001	.001	3	5
BLOOD_Lymphoma	Nucleic acid catabolic process →	+0.044	+0.034	<.001	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,192 associations by consensus.

Positive regulation of DNA repair by LHFPL4 expression — LUNG_SCLC

Explore this box plot interactively →