LHFPL3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LHFPL3 mutation is significantly associated with the RNA expression of many other genes, with 4,763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL3-associated genes across cancer lineages are ZNHIT3, RNA5SP412, and TIMM8B. Each is linked with LHFPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL3-to-partner and partner-to-LHFPL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL3→partner) and Y-score (partner→LHFPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECZNHIT3 →+0.549+3.975<.001<.00132
UCECRNA5SP412 →+0.445+1.765<.001.00132
UCECTIMM8B →+0.368+2.169.001<.00132
UCECEIF4E →+0.524+2.223<.001<.00132
UCECCENPH →+0.687+2.868<.001<.00132
UCECBUB3 →+0.604+2.169<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,763 associations by consensus.

Exploration