LHFPL2

Across TCGA patient cohorts, LHFPL2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL2-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FASN. Each is linked with LHFPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL2-to-partner and partner-to-LHFPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LHFPL2-low versus LHFPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL2→partner) and Y-score (partner→LHFPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.213	+2.459	.024	.019	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.000	.013	.032	3	1
UCEC	FASN →	+0.367	+2.000	.039	.032	2	2
UCEC	FOXO3a_pS318_S321 →	-0.152	-3.312	.007	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.485	+2.179	.034	.034	3	1
UCEC	Ku80 →	+0.231	+2.009	.030	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by LHFPL2 expression — UCEC

Explore this box plot interactively →