LHFPL1

Across TCGA patient cohorts, LHFPL1 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL1-associated genes across cancer lineages are RN7SKP286, OR4C12, and LINC02540. Each is linked with LHFPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL1-to-partner and partner-to-LHFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by LHFPL1-low versus LHFPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL1→partner) and Y-score (partner→LHFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP286 →	+0.057	+4.360	<.001	.004	3	2
LUAD	OR4C12 →	+0.019	+5.277	<.001	.001	3	2
LUAD	LINC02540 →	+0.061	+4.786	<.001	.003	3	2
LUAD	RNU6-232P →	+0.310	+5.602	<.001	.001	3	2
LUAD	MIR8086 →	+0.372	+3.552	.002	.002	3	2
SKCM	RN7SL837P →	+0.169	+6.993	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

RN7SKP286 by LHFPL1 expression — UCEC

Explore this box plot interactively →