LHFPL1

Across TCGA patient cohorts, LHFPL1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL1-associated genes across cancer lineages are ERK2, Ku80, and MSH2. Each is linked with LHFPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL1-to-partner and partner-to-LHFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LHFPL1-low versus LHFPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL1→partner) and Y-score (partner→LHFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.230	+3.321	.022	.010	3	1
UCEC	Ku80 →	+0.249	+2.183	.044	.035	3	1
UCEC	MSH2 →	-0.304	-2.973	.011	.035	3	1
UCEC	Smad4 →	-0.181	-3.150	.004	.019	3	1
UCEC	Rab25 →	-0.413	-3.321	.017	.010	2	1
UCEC	VHL →	-0.995	-3.000	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by LHFPL1 expression — UCEC

Explore this box plot interactively →