LHCGR

Across TCGA pan-cancer cohorts, LHCGR mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LHCGR data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LHCGR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LHCGR expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC and LSCC are the cancer types where LHCGR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.500	.013	20	view →
LSCC	OS	Tertile	II,III,IV	0.873	1.000	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LHCGR–UCEC (DFS)

Open the UCEC breakdown →