LHB

Across TCGA patient cohorts, LHB RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible LHB-associated GO terms across cancer lineages are Protein hydroxylation, Negative regulation of ceramide biosynthetic process, and Peptidyl-lysine hydroxylation. Each is linked with LHB in more than 20 cancer types. Because this analysis shows association rather than direction, both LHB-to-partner and partner-to-LHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein hydroxylation grouped by LHB-low versus LHB-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHB→partner) and Y-score (partner→LHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Protein hydroxylation →	+0.050	+0.763	<.001	<.001	3	21
UVM	Negative regulation of ceramide biosynthetic process →	+0.078	+0.853	<.001	.003	3	19
THYM	Peptidyl-lysine hydroxylation →	+0.081	+0.597	<.001	<.001	3	19
ESCA	Nucleotide salvage →	+0.046	+0.467	<.001	<.001	3	19
ESCA	Multi-pass transmembrane protein insertion into ER membrane →	+0.058	+0.502	.001	.001	2	19
PCPG	Galactose catabolic process →	+0.040	+0.281	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Protein hydroxylation by LHB expression — THYM

Explore this box plot interactively →