LHB

Across TCGA cell cohorts, LHB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,541 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHB-associated GO terms across cancer lineages are Progesterone biosynthetic process, Negative regulation of myoblast fusion, and Olefinic compound biosynthetic process. Each is linked with LHB in more than 19 cancer types. Because this analysis shows association rather than direction, both LHB-to-partner and partner-to-LHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Progesterone biosynthetic process grouped by LHB-low versus LHB-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHB→partner) and Y-score (partner→LHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Progesterone biosynthetic process →	-0.305	-1.514	<.001	<.001	3	20
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+1.088	.005	.002	3	10
URINARY_TRACT	Olefinic compound biosynthetic process →	-0.416	-1.232	<.001	.003	2	11
LUNG_NSCLC_LUSC	C21-steroid hormone biosynthetic process →	-0.240	-1.092	.005	.007	3	9
PANCREAS	Regulation of protein localization to mitochondrion →	+0.093	+0.784	.001	.001	3	8
BREAST	Regulation of myoblast fusion →	+0.107	+0.647	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,541 associations by consensus.

Progesterone biosynthetic process by LHB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →