LGSN

Across TCGA patient cohorts, LGSN protein abundance is significantly associated with the RNA expression of many other genes, with 4,405 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible LGSN-associated genes across cancer lineages are GBE1, FLNC, and ANKRD1. Each is linked with LGSN in more than 3 cancer types. Because this analysis shows association rather than direction, both LGSN-to-partner and partner-to-LGSN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGSN versus GBE1 in CCRCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGSN→partner) and Y-score (partner→LGSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GBE1 →	+0.983	+1.011	<.001	<.001	3	4
HNSC	FLNC →	+1.480	+0.314	.001	.006	3	3
HNSC	ANKRD1 →	+1.597	+0.313	.008	.001	3	3
UCEC	PRICKLE2 →	+0.881	+0.768	<.001	.001	3	3
COAD	SUSD2 →	+0.987	+0.887	.001	<.001	3	3
HNSC	SHQ1 →	+0.372	+0.336	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,405 associations by consensus.

LGSN vs GBE1 — CCRCC

Explore this scatter interactively →