LGSN

Across TCGA patient cohorts, LGSN mutation is significantly associated with the RNA expression of many other genes, with 2,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGSN-associated genes across cancer lineages are KCTD9, TAF9, and UFSP2. Each is linked with LGSN in more than 2 cancer types. Because this analysis shows association rather than direction, both LGSN-to-partner and partner-to-LGSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by LGSN-low versus LGSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGSN→partner) and Y-score (partner→LGSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.599	+2.721	<.001	.003	3	3
UCEC	TAF9 →	+0.644	+4.021	<.001	<.001	3	3
UCEC	UFSP2 →	+0.356	+2.606	.006	.005	3	3
UCEC	PDHX →	+0.460	+2.702	<.001	<.001	3	3
UCEC	PIMREG →	+0.696	+1.960	.001	<.001	3	3
UCEC	NARS1 →	+0.379	+2.839	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,909 associations by consensus.

KCTD9 by LGSN expression — UCEC

Explore this box plot interactively →