LGSN

Across TCGA patient cohorts, LGSN mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGSN-associated genes across cancer lineages are ASNS, Cyclin-E2, and ACVRL1. Each is linked with LGSN in more than 2 cancer types. Because this analysis shows association rather than direction, both LGSN-to-partner and partner-to-LGSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LGSN-low versus LGSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGSN→partner) and Y-score (partner→LGSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.482	+2.415	<.001	.003	3	3
LUSC	Cyclin-E2 →	+0.149	+3.009	.024	.019	3	2
SKCM	ACVRL1 →	+0.098	+1.427	.038	.025	3	2
SKCM	p27 →	+0.123	+1.824	.046	.013	3	2
SKCM	AMPK_alpha →	+0.124	+2.000	.009	.029	3	2
UCEC	eIF4E →	+0.241	+2.459	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by LGSN expression — UCEC

Explore this box plot interactively →