LGR6

Across TCGA pan-cancer cohorts, LGR6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LGR6 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LGR6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LGR6 expression acts as an unfavorable survival marker.

LUAD, HNSC, and OV are the cancer types where LGR6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.172	0.673	<.001	32	view →
HNSC	DFS	Median	II,III,IV	0.181	0.597	<.001	20	view →
OV	OS	Median	IV	0.022	0.760	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.166	0.525	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LGR6–LUAD (OS)

Open the LUAD breakdown →