LGR6

Across TCGA patient cohorts, LGR6 mutation is significantly associated with the RNA expression of many other genes, with 3,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGR6-associated genes across cancer lineages are MCM4, RAD51C, and MFN2. Each is linked with LGR6 in more than 3 cancer types. Because this analysis shows association rather than direction, both LGR6-to-partner and partner-to-LGR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM4 grouped by LGR6-low versus LGR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR6→partner) and Y-score (partner→LGR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM4 →	+0.529	+2.280	.004	<.001	3	4
UCEC	RAD51C →	+0.396	+2.283	<.001	<.001	3	4
UCEC	MFN2 →	+0.447	+2.850	<.001	<.001	3	4
SKCM	ITGB1BP1 →	+0.397	+2.208	<.001	.001	3	4
UCEC	PSMC3IP →	+0.543	+2.010	<.001	<.001	3	4
UCEC	RPA1 →	+0.495	+1.776	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,790 associations by consensus.

MCM4 by LGR6 expression — UCEC

Explore this box plot interactively →