LGR6

Across TCGA patient cohorts, LGR6 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGR6-associated genes across cancer lineages are mTOR_pS2448, eEF2, and GAPDH. Each is linked with LGR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGR6-to-partner and partner-to-LGR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by LGR6-low versus LGR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR6→partner) and Y-score (partner→LGR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.111	-1.482	.023	.027	3	3
UCEC	eEF2 →	+0.332	+1.392	.004	.019	3	2
UCEC	GAPDH →	+0.363	+1.700	.040	.040	3	2
UCEC	MEK1 →	+0.451	+2.662	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.395	+2.263	<.001	<.001	3	2
UCEC	PDCD4 →	-0.497	-2.222	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by LGR6 expression — UCEC

Explore this box plot interactively →