LGR6

Across TCGA cell cohorts, LGR6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,172 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LGR6-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of syncytium formation by plasma membrane fusion, and Response to mycotoxin. Each is linked with LGR6 in more than 8 cancer types. Because this analysis shows association rather than direction, both LGR6-to-partner and partner-to-LGR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by LGR6-low versus LGR6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR6→partner) and Y-score (partner→LGR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of myoblast fusion →	+0.074	+0.599	.001	.002	3	9
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.074	+0.773	.001	.001	3	9
OVARY	Response to mycotoxin →	+0.444	+1.078	.003	.001	3	8
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.088	+1.044	<.001	.008	3	8
OVARY	Alternative mRNA splicing, via spliceosome →	+0.079	+1.118	<.001	<.001	3	8
CNS	Negative regulation of myoblast fusion →	+0.086	+0.704	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,172 associations by consensus.

Regulation of myoblast fusion by LGR6 expression — BREAST

Explore this box plot interactively →