LGR6

Across TCGA cell cohorts, LGR6 mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGR6-associated genes across cancer lineages are KRTAP5-6, OR14A2, and PRAMEF33. Each is linked with LGR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGR6-to-partner and partner-to-LGR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-6 grouped by LGR6-low versus LGR6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR6→partner) and Y-score (partner→LGR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP5-6 →	+0.205	+3.289	<.001	.009	3	2
STOMACH	OR14A2 →	+0.023	+5.285	<.001	.003	3	2
BLOOD_Myeloma	PRAMEF33 →	+0.016	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	GOLGA6L6 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MYH7 →	+0.016	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

KRTAP5-6 by LGR6 expression — BLOOD_Leukemia

Explore this box plot interactively →