LGR5

Across TCGA patient cohorts, LGR5 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,961 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGR5-associated proteins across cancer lineages are ENPP1, PALLD, and SDC2. Each is linked with LGR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGR5 versus ENPP1 in LSCC, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENPP1 →	+0.616	+0.984	<.001	<.001	3	4
LSCC	PALLD →	+0.432	+1.152	.001	.009	3	4
HNSC	SDC2 →	+0.686	+0.976	<.001	.001	3	4
PDAC	EFEMP2 →	+0.615	+0.964	<.001	.001	3	4
LUAD	SEC24A →	-0.264	-1.194	<.001	<.001	3	4
PDAC	EPB41L2_S550 →	+0.637	+0.875	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,961 associations by consensus.

LGR5 vs ENPP1 — LSCC

Explore this scatter interactively →