LGR5

Across TCGA patient cohorts, LGR5 protein abundance is significantly associated with the RNA expression of many other genes, with 1,752 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGR5-associated genes across cancer lineages are IQCH, LACTB, and SPAG1. Each is linked with LGR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGR5 versus IQCH in UCEC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IQCH →	-0.594	-0.477	<.001	.008	3	1
UCEC	LACTB →	-0.509	-0.896	<.001	<.001	3	1
UCEC	SPAG1 →	-0.626	-0.586	.003	<.001	3	1
UCEC	CCNP →	-0.517	-0.486	<.001	.006	3	1
UCEC	HTATIP2 →	-0.884	-0.782	.006	.004	3	1
UCEC	SOX6 →	+1.069	+0.859	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,752 associations by consensus.

LGR5 vs IQCH — UCEC

Explore this scatter interactively →