LGR5

Across TCGA patient cohorts, LGR5 mutation is significantly associated with the RNA expression of many other genes, with 3,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGR5-associated genes across cancer lineages are BBS7, SNORD90, and AURKA. Each is linked with LGR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by LGR5-low versus LGR5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BBS7 →	+0.393	+2.294	.006	<.001	3	4
SKCM	SNORD90 →	+0.095	+2.173	<.001	.005	3	3
UCEC	AURKA →	+0.720	+2.938	.001	<.001	3	3
SKCM	LACTB →	+0.570	+2.832	<.001	.001	3	3
UCEC	KCTD9 →	+0.732	+2.470	<.001	<.001	3	3
UCEC	POLR1F →	+0.415	+2.102	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,970 associations by consensus.

BBS7 by LGR5 expression — SKCM

Explore this box plot interactively →