LGR5

Across TCGA patient cohorts, LGR5 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGR5-associated genes across cancer lineages are Annexin-1, AR, and Shc_pY317. Each is linked with LGR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by LGR5-low versus LGR5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Annexin-1 →	+0.498	+2.816	.025	.036	3	3
UCEC	AR →	-0.310	-1.415	.026	.046	3	3
UCEC	Shc_pY317 →	-0.242	-2.662	<.001	<.001	3	2
UCEC	IGFBP2 →	-0.689	-2.321	.004	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.218	-2.156	<.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.127	-1.861	.023	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Annexin-1 by LGR5 expression — LUSC

Explore this box plot interactively →