LGR5

Across TCGA cell cohorts, LGR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,494 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LGR5-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Negative regulation of syncytium formation by plasma membrane fusion, and Nucleosome organization. Each is linked with LGR5 in more than 8 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by LGR5-low versus LGR5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.097	+1.800	<.001	<.001	3	9
BONE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.095	+1.618	.001	<.001	3	8
BLOOD_Lymphoma	Nucleosome organization →	+0.062	+0.053	<.001	.009	2	8
BONE	Regulation of myoblast fusion →	+0.118	+1.909	<.001	<.001	3	7
LUNG_NSCLC_LUAD	DNA-templated transcription initiation →	+0.027	+0.309	<.001	.001	3	6
LUNG_NSCLC_LUAD	Transcription initiation at RNA polymerase II promoter →	+0.031	+0.369	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

Positive regulation of double-strand break repair by LGR5 expression — BONE

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