LGR5

Across TCGA cell cohorts, LGR5 mutation is significantly associated with the RNA expression of many other genes, with 476 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGR5-associated genes across cancer lineages are C20orf85, OR1L4, and OR4D6. Each is linked with LGR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGR5-to-partner and partner-to-LGR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by LGR5-low versus LGR5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR5→partner) and Y-score (partner→LGR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR51L1 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR51G2 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	FAM47A →	+0.006	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

C20orf85 by LGR5 expression — SOFT_TISSUE

Explore this box plot interactively →