Across TCGA patient cohorts, LGR4 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,817 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LGR4-associated proteins across cancer lineages are RBM47, CTNNA1, and PKP4_S776. Each is linked with LGR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LGR4-to-partner and partner-to-LGR4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR4→partner) and Y-score (partner→LGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBM47 →	+0.463	+0.917	<.001	<.001	3	5
CCRCC	CTNNA1 →	+0.263	+0.544	<.001	.001	3	5
PDAC	PKP4_S776 →	+0.497	+0.345	.006	.005	3	4
LUAD	PLEKHA7_S903 →	+0.703	+0.896	.002	.001	3	4
PDAC	TJP3_S203 →	+0.628	+0.761	<.001	<.001	3	4
CCRCC	SULF2 →	-0.505	-0.801	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,817 associations by consensus.

Exploration

LGR4 survival (RNA) · tumor vs normal (RNA) · all LGR4 data types