Across TCGA patient cohorts, LGR4 protein abundance is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LGR4-associated genes across cancer lineages are CYCSP11, RN7SKP198, and NELFCD. Each is linked with LGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGR4-to-partner and partner-to-LGR4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR4→partner) and Y-score (partner→LGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYCSP11 →	-1.166	-0.286	.004	.006	3	2
UCEC	RN7SKP198 →	-1.256	-0.212	.005	.006	3	2
GBM	NELFCD →	-0.481	-0.545	<.001	<.001	3	1
GBM	TTI1 →	-0.605	-0.517	<.001	<.001	3	1
GBM	NUTF2 →	-0.342	-0.368	<.001	.003	3	1
GBM	CTCF →	-0.433	-0.458	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

Exploration

LGR4 survival (RNA) · tumor vs normal (RNA) · all LGR4 data types