Across TCGA patient cohorts, LGR4 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGR4-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and YAP_pS127. Each is linked with LGR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LGR4-to-partner and partner-to-LGR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR4→partner) and Y-score (partner→LGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.313	+3.000	.015	.035	3	5
COAD	Caspase-7-cleavedD198 →	+1.432	+3.321	<.001	.009	3	4
COAD	YAP_pS127 →	-0.313	-3.000	.012	.034	3	3
UCEC	eIF4E →	+0.172	+2.201	.014	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.390	-1.571	.009	.009	3	3
COAD	INPP4B →	-0.468	-2.450	.003	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

LGR4 survival (RNA) · tumor vs normal (RNA) · all LGR4 data types