Across TCGA cell cohorts, LGR4 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGR4-associated genes across cancer lineages are BMP15, NLRP8, and OR5P2. Each is linked with LGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGR4-to-partner and partner-to-LGR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGR4→partner) and Y-score (partner→LGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	2
BLOOD_Lymphoma	OR5P2 →	+0.021	+4.867	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	AVP →	+0.038	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IFNA6 →	+0.171	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

Exploration

LGR4 survival (RNA) · tumor vs normal (RNA) · all LGR4 data types