Across TCGA pan-cancer cohorts, LGMNP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LGMNP1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LGMNP1 RNA is repressed in tumor relative to normal tissue. In most cancer types LGMNP1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.
THCA, KICH, and UCEC are the cancer types where LGMNP1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGMNP1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.