LGI4

Across TCGA pan-cancer cohorts, LGI4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LGI4 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LGI4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LGI4 expression acts as an unfavorable survival marker.

CCRCC, HNSC, and LUAD are the cancer types where LGI4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.379	0.949	.017	4	view →
HNSC	DFS	Tertile	II,III,IV	0.666	0.948	.026	4	view →
LUAD	DFS	Median	II,III,IV	0.615	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

LGI4–CCRCC (DFS)

Open the CCRCC breakdown →