LGI4

Across TCGA patient cohorts, LGI4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,091 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI4-associated proteins across cancer lineages are NID2, PPP1R12B, and CNRIP1. Each is linked with LGI4 in more than 6 cancer types. Because this analysis shows association rather than direction, both LGI4-to-partner and partner-to-LGI4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI4 versus NID2 in OV, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI4→partner) and Y-score (partner→LGI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NID2 →	+0.534	+0.571	<.001	<.001	3	7
COAD	PPP1R12B →	+0.743	+0.627	<.001	<.001	3	7
UCEC	CNRIP1 →	+0.902	+0.636	<.001	<.001	3	7
UCEC	ANK2 →	+0.439	+0.451	<.001	<.001	3	7
GBM	TMOD2 →	+0.615	+1.374	<.001	<.001	3	7
BRCA	PALM →	+0.751	+0.622	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,091 associations by consensus.

LGI4 vs NID2 — OV

Explore this scatter interactively →