LGI4

Across TCGA patient cohorts, LGI4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,158 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI4-associated genes across cancer lineages are PABPC5, PDE1B, and SNCG. Each is linked with LGI4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGI4-to-partner and partner-to-LGI4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI4 versus PABPC5 in LSCC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI4→partner) and Y-score (partner→LGI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PABPC5 →	+0.455	+0.581	.003	.001	3	3
LSCC	PDE1B →	+0.732	+0.653	.002	.001	3	3
COAD	SNCG →	+1.211	+0.976	<.001	.005	3	2
COAD	DES →	+4.679	+1.072	.001	.001	2	3
COAD	PSD →	+1.408	+1.072	.007	.001	3	2
CCRCC	GSTM5 →	+0.702	+1.937	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,158 associations by consensus.

LGI4 vs PABPC5 — LSCC

Explore this scatter interactively →