LGI4

Across TCGA patient cohorts, LGI4 mutation is significantly associated with the RNA expression of many other genes, with 1,975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGI4-associated genes across cancer lineages are CCL5, CCL4, and RNA5SP411. Each is linked with LGI4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGI4-to-partner and partner-to-LGI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL5 grouped by LGI4-low versus LGI4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI4→partner) and Y-score (partner→LGI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL5 →	+0.796	+1.923	.007	.009	3	2
COAD	CCL4 →	+1.342	+3.459	<.001	.005	3	2
UCEC	RNA5SP411 →	+0.875	+1.891	<.001	<.001	3	2
COAD	CCL3 →	+1.182	+3.342	.001	.005	3	2
LUAD	LINC02353 →	+0.250	+5.044	<.001	.009	3	2
SKCM	RN7SL560P →	+0.087	+3.360	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,975 associations by consensus.

CCL5 by LGI4 expression — UCEC

Explore this box plot interactively →