LGI4

Across TCGA patient cohorts, LGI4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGI4-associated genes across cancer lineages are Notch1, Dvl3, and eIF4E. Each is linked with LGI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI4-to-partner and partner-to-LGI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LGI4-low versus LGI4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI4→partner) and Y-score (partner→LGI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.121	+1.594	.014	.021	3	2
COAD	Dvl3 →	+0.242	+3.178	.017	.010	3	1
UCEC	eIF4E →	+0.207	+2.713	.005	.003	3	1
UCEC	ERK2 →	+0.165	+1.700	.015	.040	3	1
UCEC	FOXO3a_pS318_S321 →	-0.120	-2.492	.006	.001	3	1
UCEC	ACC1 →	+0.286	+2.000	.025	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by LGI4 expression — UCEC

Explore this box plot interactively →