LGI4

Across TCGA cell cohorts, LGI4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LGI4-associated genes across cancer lineages are DAZ4, DAZ2, and RBMY1J. Each is linked with LGI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI4-to-partner and partner-to-LGI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ4 grouped by LGI4-low versus LGI4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI4→partner) and Y-score (partner→LGI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DAZ4 →	+0.164	+3.977	<.001	.001	3	1
LARGE_INTESTINE	DAZ2 →	+0.170	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
LUNG_NSCLC_LUAD	IL2 →	+0.043	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF10 →	+0.012	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DAZ4 by LGI4 expression — LARGE_INTESTINE

Explore this box plot interactively →