LGI3

Across TCGA patient cohorts, LGI3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,809 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI3-associated genes across cancer lineages are QDPR, TMEM88B, and LINC01792. Each is linked with LGI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI3 versus QDPR in GBM, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	QDPR →	+0.937	+0.931	<.001	<.001	3	2
GBM	TMEM88B →	+1.235	+0.812	<.001	<.001	3	2
GBM	LINC01792 →	+0.669	+0.819	<.001	<.001	3	2
GBM	PIK3IP1 →	+0.555	+0.673	<.001	<.001	3	1
GBM	CRYBB1 →	+0.702	+0.839	.003	.002	3	1
GBM	SOX10 →	+1.470	+0.952	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,809 associations by consensus.

LGI3 vs QDPR — GBM

Explore this scatter interactively →