LGI3

Across TCGA patient cohorts, LGI3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGI3-associated genes across cancer lineages are EGFR_pY1068, Rad50, and Annexin-1. Each is linked with LGI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LGI3-low versus LGI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.229	-1.906	.009	.015	3	2
UCEC	Rad50 →	-0.208	-2.571	.015	.010	3	2
UCEC	Annexin-1 →	+0.493	+2.434	.008	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.555	+2.341	.008	.003	3	2
UCEC	c-Kit →	-0.199	-2.000	.016	.003	3	2
UCEC	A-Raf_pS299 →	-0.098	-2.115	.019	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by LGI3 expression — UCEC

Explore this box plot interactively →