LGI3

Across TCGA cell cohorts, LGI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,114 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LGI3-associated GO terms across cancer lineages are Aerobic respiration, Aerobic electron transport chain, and ATP metabolic process. Each is linked with LGI3 in more than 13 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by LGI3-low versus LGI3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Aerobic respiration →	+0.089	+2.727	<.001	<.001	3	14
OVARY	Aerobic electron transport chain →	+0.095	+0.219	<.001	.008	3	13
LUNG_NSCLC_LUSC	ATP metabolic process →	+0.098	+0.121	<.001	<.001	3	12
OVARY	Mitochondrial electron transport, cytochrome c to oxygen →	+0.104	+0.299	<.001	.002	3	12
URINARY_TRACT	Purine nucleoside triphosphate metabolic process →	+0.074	+0.315	<.001	.005	3	12
OESOPHAGUS	Purine nucleoside triphosphate biosynthetic process →	+0.158	+0.317	.001	.009	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,114 associations by consensus.

Aerobic respiration by LGI3 expression — SKIN

Explore this box plot interactively →