LGI3

Across TCGA cell cohorts, LGI3 mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGI3-associated genes across cancer lineages are AGI-6780, Oxaliplatin, and Sinularin. Each is linked with LGI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by LGI3-low versus LGI3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.423	+2.646	.029	.047	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.523	+2.649	.049	.046	3	1
LARGE_INTESTINE	Sinularin →	+0.469	+2.777	.002	.038	3	1
LARGE_INTESTINE	eEF2K Inhibitor →	+0.231	+2.652	.038	.045	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.302	+2.649	.033	.046	2	1
LARGE_INTESTINE	JAK1_8709 →	+0.604	+2.649	.001	.046	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

AGI-6780 by LGI3 expression — LARGE_INTESTINE

Explore this box plot interactively →