LGI2

Across TCGA patient cohorts, LGI2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,127 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LGI2-associated proteins across cancer lineages are PTGIS, AFAP1, and THBS3. Each is linked with LGI2 in more than 7 cancer types. Because this analysis shows association rather than direction, both LGI2-to-partner and partner-to-LGI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI2 versus PTGIS in CCRCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI2→partner) and Y-score (partner→LGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTGIS →	+0.988	+0.809	<.001	<.001	3	8
UCEC	AFAP1 →	+0.540	+1.067	<.001	<.001	3	8
CCRCC	THBS3 →	+0.979	+0.800	<.001	<.001	3	7
COAD	TPM1 →	+0.833	+0.697	<.001	<.001	3	7
UCEC	PRKG1 →	+0.661	+0.863	<.001	<.001	3	7
CCRCC	PDLIM7 →	+1.015	+0.730	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,127 associations by consensus.

LGI2 vs PTGIS — CCRCC

Explore this scatter interactively →