LGI2

Across TCGA patient cohorts, LGI2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,379 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI2-associated genes across cancer lineages are VEGFC, EDIL3, and DACT1. Each is linked with LGI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGI2-to-partner and partner-to-LGI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI2 versus VEGFC in CCRCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI2→partner) and Y-score (partner→LGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VEGFC →	+0.906	+0.514	.003	.002	3	2
CCRCC	EDIL3 →	+1.567	+0.470	<.001	.007	3	2
BRCA	DACT1 →	+1.820	+1.254	.003	.003	2	3
GBM	SLC6A17 →	+1.632	+0.594	<.001	<.001	3	2
CCRCC	CD24P2 →	-0.981	-0.512	.002	.002	3	2
BRCA	ARHGAP23 →	+1.115	+1.254	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,379 associations by consensus.

LGI2 vs VEGFC — CCRCC

Explore this scatter interactively →