LGI2

Across TCGA cell cohorts, LGI2 RNA expression is significantly associated with the RNA expression of many other genes, with 3,694 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LGI2-associated genes across cancer lineages are CHRD, CCDC149, and NAT8L. Each is linked with LGI2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LGI2-to-partner and partner-to-LGI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI2 versus CHRD in CNS, with a Pearson correlation of 0.47.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI2→partner) and Y-score (partner→LGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CHRD →	+1.144	+0.808	<.001	.001	3	6
BLOOD_Leukemia	CCDC149 →	+1.843	+0.439	<.001	<.001	3	5
OESOPHAGUS	NAT8L →	+1.525	+0.480	<.001	.004	3	4
BREAST	PPP1R1A →	+0.945	+0.296	.001	.003	3	4
LUNG_NSCLC_LUSC	EFR3B →	+1.480	+0.478	.001	.001	3	4
LUNG_SCLC	KIF1A →	+2.606	+1.181	.003	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

LGI2 vs CHRD — CNS

Explore this scatter interactively →