LGI2

Across TCGA cell cohorts, LGI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,555 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LGI2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Heterochromatin formation. Each is linked with LGI2 in more than 8 cancer types. Because this analysis shows association rather than direction, both LGI2-to-partner and partner-to-LGI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by LGI2-low versus LGI2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI2→partner) and Y-score (partner→LGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Epigenetic regulation of gene expression →	+0.037	+0.292	.002	.005	2	9
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.056	+0.600	.004	.008	2	9
CNS	Heterochromatin formation →	+0.024	+0.400	.009	.008	3	8
LUNG_SCLC	Cartilage development →	-0.086	-1.691	<.001	<.001	3	7
OESOPHAGUS	Positive regulation of monoatomic ion transport →	-0.095	-0.585	<.001	<.001	3	7
OESOPHAGUS	Heart contraction →	-0.137	-0.407	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,555 associations by consensus.

Epigenetic regulation of gene expression by LGI2 expression — BREAST

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