LGALS9

Across TCGA patient cohorts, LGALS9 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS9-associated genes across cancer lineages are ATM, YAP_pS127, and A-Raf_pS299. Each is linked with LGALS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS9-to-partner and partner-to-LGALS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LGALS9-low versus LGALS9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS9→partner) and Y-score (partner→LGALS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.466	-2.986	.027	.035	3	2
SKCM	YAP_pS127 →	-0.421	-3.000	.023	.035	3	1
UCEC	A-Raf_pS299 →	-0.110	-3.321	.049	.010	3	1
UCEC	JNK2 →	+0.235	+2.179	.011	.034	3	1
UCEC	MEK1 →	+0.419	+2.321	.014	.034	3	1
UCEC	beta-Catenin →	+0.531	+2.999	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by LGALS9 expression — UCEC

Explore this box plot interactively →