LGALS9

Across TCGA cell cohorts, LGALS9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,462 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LGALS9-associated GO terms across cancer lineages are Negative regulation of mast cell degranulation, Negative regulation of myeloid leukocyte mediated immunity, and Negative regulation of IP-10 production. Each is linked with LGALS9 in more than 19 cancer types. Because this analysis shows association rather than direction, both LGALS9-to-partner and partner-to-LGALS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mast cell degranulation grouped by LGALS9-low versus LGALS9-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS9→partner) and Y-score (partner→LGALS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of mast cell degranulation →	+2.034	+4.402	<.001	<.001	3	20
STOMACH	Negative regulation of myeloid leukocyte mediated immunity →	+2.384	+4.417	<.001	<.001	3	19
BREAST	Negative regulation of IP-10 production →	+1.317	+3.342	<.001	<.001	3	14
STOMACH	Negative regulation of chemokine production →	+0.173	+3.521	<.001	<.001	2	15
BREAST	Negative regulation of regulatory T cell differentiation →	+0.224	+3.062	<.001	<.001	3	14
BREAST	Intrinsic apoptotic signaling pathway →	+0.056	+2.552	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,462 associations by consensus.

Negative regulation of mast cell degranulation by LGALS9 expression — STOMACH

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