LGALS3BP

Across TCGA patient cohorts, LGALS3BP mutation is significantly associated with the RNA expression of many other genes, with 824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS3BP-associated genes across cancer lineages are SYNJ2BP-COX16, LINC02559, and SETD3. Each is linked with LGALS3BP in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS3BP-to-partner and partner-to-LGALS3BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNJ2BP-COX16 grouped by LGALS3BP-low versus LGALS3BP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS3BP→partner) and Y-score (partner→LGALS3BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SYNJ2BP-COX16 →	+0.425	+3.491	<.001	.002	3	2
CESC	LINC02559 →	+0.674	+4.342	<.001	.007	3	2
UCEC	SETD3 →	+0.367	+2.828	.002	.001	3	2
UCEC	RPL23AP82 →	+0.349	+2.721	.002	.003	3	2
UCEC	IFRD2 →	+0.385	+2.628	.008	.005	3	2
UCEC	SBDSP1 →	+0.721	+2.721	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 824 associations by consensus.

SYNJ2BP-COX16 by LGALS3BP expression — SKCM

Explore this box plot interactively →