LGALS3

Across TCGA patient cohorts, LGALS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,658 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGALS3-associated proteins across cancer lineages are ERO1A, CAST, and ARF6. Each is linked with LGALS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both LGALS3-to-partner and partner-to-LGALS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGALS3 versus ERO1A in GBM, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS3→partner) and Y-score (partner→LGALS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERO1A →	+0.721	+1.194	<.001	<.001	3	6
UCEC	CAST →	+0.494	+0.829	<.001	<.001	3	6
LSCC	ARF6 →	+0.312	+0.665	<.001	<.001	3	6
OV	EPS8L2 →	+0.755	+1.299	<.001	<.001	3	5
LSCC	AHNAK2 →	+0.933	+0.626	.001	.002	3	5
BRCA	AHNAK2_S1418 →	+1.003	+1.035	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,658 associations by consensus.

LGALS3 vs ERO1A — GBM

Explore this scatter interactively →